Postdoctoral Fellow, AIDS Institute
Contact Information
Email: hexen@hku.hk
Research Description
Immunotherapy hold a promising target of functional cure for long-term HIV-1 suppression. My research focuses on developing an immunotherapy for HIV infection in rhesus model combining with bi-bNAb (BiIA-SG) and rhPD1-p27 DNA vaccine. Hopefully this strategy will provide a new immunotherapy for HIV functional cure. And more and more efficient bi-bNAb or vaccine will be testified on macaques in future.
Focus on
1. The development of immunotherapy on SHIV infected macaque
2. The immue features of elderly monkeys with SHIV supression
Selected Publication
First/Co-First Author
He X†, Wong YC†, Zhong M†, Mo Y†, Li B, Yim LY, Li X, Liu W, Du Y, Wang H, Zhang H, Chen Z. A follow-up study: 6-year cART-free virologic control of rhesus macaques after PD-1-based DNA vaccination against pathogenic SHIVSF162P3CN challenge. Microbiol Spectr. 2023 Dec 12;11(6):e0335023. doi: 10.1128/spectrum.03350-23. (†Co-first author)
He X†, Lang X†, Yu J†, Zhu L†, Qin Z, Liu X, Chen P, Dai C, Chen T, Li X, Chen Y, Zhou D, Fang W, Xiao W, Zhang B, Xie Q, Wu Q, Zhao W. The effects of Japanese encephalitis virus antibodies on Zika virus infection. Med Microbiol Immunol. 2020 Apr;209(2):177-188. doi: 10.1007/s00430-020-00658-2.(†Co-first author)
Yu J†, Qin Z†, Liu X†, He X†, Yao J, Zhou X, Wen K, Yu N, Wu Q, Xiao W, Zhu L, Wan C, Zhang B, Zhao W. High-specificity targets in SARS-CoV-2 N protein for serological detection and distinction from SARS-CoV. Comput Biol Med. 2022 Apr;143:105272. doi: 10.1016/j.compbiomed.2022.105272. († Co-first author)
Qin Z†, Chen Y†, Yu J†, He X†, Liu X, Zhu L, Wu Q, Wan C, Zhang B, Zhao W. Rapid Construction of an Infectious Clone of the Zika Virus, Strain ZKC2. Front Microbiol. 2021 Oct 21;12:752578. doi: 10.3389/fmicb.2021.752578. († Co-first author)