Research Interest
Metabolic remodelling is required for B cell activation and antibody production, while B cell dysfunction is frequently observed in patients with viral infections, such as HIV-1 and SARS-CoV-2. Moreover, viruses have developed numerous mechanisms to evade immunosurveillance by inducing metabolic rewiring and immune dysregulation. My study aims to investigate the key role of an isoform of PD-1, Δ42PD1, spike protein of SARS-CoV-2, and pro-inflammatory cytokines in regulating cellular and metabolic signalling, thus how they shape B cell fate and function.
Publications
- Cao T, Liu L, To KK, Lim CY, Zhou R, Ming Y, Kwan KY, Yu S, Chan CY, Zhou B, Huang H, Mo Y, Du Z, Gong R, Yat LT, Hung IF, Tam AR, To WK, Leung WS, Chik TS, Tsang OT, Lin X, Song YQ, Yuen KY, Chen Z. Mitochondrial regulation of acute extrafollicular B-cell responses to COVID-19 severity. Clin Transl Med. 2022 Sep;12(9):e1025. doi: 10.1002/ctm2.1025. PMID: 36103567; PMCID: PMC9473490.
- Mo Y, Yue M, Yim LY, Zhou R, Yu C, Peng Q, Zhou Y, Luk TY, Lui GC, Huang H, Lim CYH, Wang H, Liu L, Sun H, Wang J, Song Y, Chen Z. Nicotinamide mononucleotide impacts HIV-1 infection by modulating immune activation in T lymphocytes and humanized mice. EBioMedicine. 2023 Dec;98:104877. doi: 10.1016/j.ebiom.2023.104877. Epub 2023 Nov 17. PMID: 37980794; PMCID: PMC10694053.
- Mo Y, To KK, Zhou R, Liu L, Cao T, Huang H, Du Z, Lim CYH, Yim LY, Luk TY, Chan JM, Chik TS, Lau DP, Tsang OT, Tam AR, Hung IF, Yuen KY, Chen Z. Mitochondrial Dysfunction Associates With Acute T Lymphocytopenia and Impaired Functionality in COVID-19 Patients. Front Immunol. 2022 Jan 14;12:799896. doi: 10.3389/fimmu.2021.799896. PMID: 35095881; PMCID: PMC8795605.
- Liu Q, Kwan KY, Cao T, Yan B, Ganesan K, Jia L, Zhang F, Lim C, Wu Y, Feng Y, Chen Z, Liu L, Chen J. Broad-spectrum antiviral activity of Spatholobus suberectus Dunn against SARS-CoV-2, SARS-CoV-1, H5N1, and other enveloped viruses. Phytother Res. 2022 Aug;36(8):3232-3247. doi: 10.1002/ptr.7452. PMID: 35943221; PMCID: PMC9537938.